NLP4Health Lab Amsterdam

Falls involve dynamic risk factors that change over time, but most studies on fall-risk factors are cross-sectional and do not capture this temporal aspect. The longitudinal clinical notes within electronic health records (EHR) provide an opportunity to analyse fall risk factor trajectories through Natural Language Processing techniques, specifically dynamic topic modelling (DTM). This study aims to uncover fall-related topics for new fallers and track their evolving trends leading up to falls.This case–cohort study utilised primary care EHR data covering information on older adults between 2016 and 2019. Cases were individuals who fell in 2019 but had no falls in the preceding three years (2016–18). The control group was randomly sampled individuals, with similar size to the cases group, who did not endure falls during the whole study follow-up period. We applied DTM on the clinical notes collected between 2016 and 2018. We compared the trend lines of the case and control groups using the slopes, which indicate direction and steepness of the change over time.A total of 2,384 fallers (cases) and an equal number of controls were included. We identified 25 topics that showed significant differences in trends between the case and control groups. Topics such as medications, renal care, family caregivers, hospital admission/discharge and referral/streamlining diagnostic pathways exhibited a consistent increase in steepness over time within the cases group before the occurrence of falls.Early recognition of health conditions demanding care is crucial for applying proactive and comprehensive multifactorial assessments that address underlying causes, ultimately reducing falls and fall-related injuries.

Developing artificial learning systems that can understand and generate natural language has been one of the long-standing goals of artificial intelligence. Recent decades have witnessed an impressive progress on both of these problems, giving rise to a new family of approaches. Especially, the advances in deep learning over the past couple of years have led to neural approaches to natural language generation (NLG). These methods combine generative language learning techniques with neural-networks based frameworks. With a wide range of applications in natural language processing, neural NLG (NNLG) is a new and fast growing field of research. In this state-of-the-art report, we investigate the recent developments and applications of NNLG in its full extent from a multidimensional view, covering critical perspectives such as multimodality, multilinguality, controllability and learning strategies. We summarize the fundamental building blocks of NNLG approaches from these aspects and provide detailed reviews of commonly used preprocessing steps and basic neural architectures. This report also focuses on the seminal applications of these NNLG models such as machine translation, description generation, automatic speech recognition, abstractive summarization, text simplification, question answering and generation, and dialogue generation. Finally, we conclude with a thorough discussion of the described frameworks by pointing out some open research directions.

In recent years, there has been a surge in interest in using natural language processing (NLP) applications for clinical psychology and psychiatry. Despite the increased societal, economic, and academic interest, there has been no systematic critical analysis of the recent progress in NLP applications for mental disorders, or of the resources available for training and evaluating such systems. This chapter addresses this gap through two main contributions. First, it provides an overview of the NLP literature related to mental disorders, with a focus on autism, dyslexia, schizophrenia, depression and mental health in general. We discuss the strengths and shortcomings of current methodologies, specifically focusing on the challenges in obtaining large volumes of high-quality domain-specific data both for English and for lower-resource languages. We also provide a list of datasets publicly available for researchers who would like to develop NLP methods for specific mental disorders, categorized according to relevant criteria such as data source, language, annotation, and size. Our second contribution is a discussion on how to support the application of these methods to various languages and social contexts. This includes recommendations on conducting robust and ethical experiments from a machine learning perspective, and a discussion on how techniques such as cross-lingual transfer learning could be applied within this area.

In this paper we give a narrative review of multi-modal video-language (VidL) models. We introduce the current landscape of VidL models and benchmarks, and draw inspiration from neuroscience and cognitive science to propose avenues for future research in VidL models in particular and artificial intelligence (AI) in general. We argue that iterative feedback loops between AI, neuroscience, and cognitive science are essential to spur progress across these disciplines. We motivate why we focus specifically on VidL models and their benchmarks as a promising type of model to bring improvements in AI and categorise current VidL efforts across multiple’cognitive relevance axioms’. Finally, we provide suggestions on how to effectively incorporate this interdisciplinary viewpoint into research on VidL models in particular and AI in general. In doing so, we hope to create awareness of the potential of VidL models to narrow the gap between neuroscience, cognitive science, and AI.

Purpose To investigate drug-related causes attributed to acute kidney injury (DAKI) and their documentation in patients admitted to the Intensive Care Unit (ICU). Methods This study was conducted in an academic hospital in the Netherlands by reusing electronic health record (EHR) data of adult ICU admissions between November 2015 to January 2020. First, ICU admissions with acute kidney injury (AKI) stage 2 or 3 were identified. Subsequently, three modes of DAKI documentation in EHR were examined: diagnosis codes (structured data), allergy module (semi-structured data), and clinical notes (unstructured data). Results n total 8124 ICU admissions were included, with 542 (6.7%) ICU admissions experiencing AKI stage 2 or 3. The ICU physicians deemed 102 of these AKI cases (18.8%) to be drug-related. These DAKI cases were all documented in the clinical notes (100%), one in allergy module (1%) and none via diagnosis codes. The clinical notes required the highest time investment to analyze. Conclusions Drug-related causes comprise a substantial part of AKI in the ICU patients. However, current unstructured DAKI documentation practice via clinical notes hampers our ability to gain better insights about DAKI occurrence. Therefore, both automating DAKI identification from the clinical notes and increasing structured DAKI documentation should be encouraged.

We examine the use of large Transformer-based pretrained language models (PLMs) for the problem of early prediction of lung cancer using free-text patient medical notes of Dutch primary care physicians. Specifically, we investigate: 1) how soft prompt-tuning compares to standard model fine-tuning; 2) whether simpler static word embedding models (WEMs) can be more robust compared to PLMs in highly imbalanced settings; and 3) how models fare when trained on notes from a small number of patients. All our code is available open source in https://bitbucket.org/aumc-kik/prompt_tuning_cancer_prediction/.